Showing posts with label research. Show all posts
Showing posts with label research. Show all posts

Thursday, March 28, 2013

Partners in Change

Friends and Family --

My entry from the aforementioned New Experiences in Narrative essay collection is now live on the Fogarty Scholars website. You can read all about one of the most memorable experiences I had during my Fulbright-Fogarty Fellowship year in Durban, and why I am so enthusiastic about the work I have been able to accomplish during my time in South Africa. Thanks for checking it out:

http://bit.ly/partnersinchange

In other exciting news, I am headed to the Massachusetts General Hospital for my residency in Internal Medicine. Smarter Than the Average Bearnot is headed to Boston. Huzzah!

Tuesday, July 8, 2008

Oh, it's only a flesh wound. Pass me that plastic bear, would you?

From NYU's internal medicine blog, Clinical Correlations, a scientific update on the powerful but previously poorly-described anti-bacterial powers of honey:

Every once in a while when reviewing articles to be included in this section, I find one that makes me smile. An article featured in this week’s Clinical Infectious Disease was titled “Medical-Grade Honey Kills Antibiotic-Resistant Bacteria In Vitro and Eradicates Skin Colonization. The investigators studied Revamil, a medical-grade honey, to assess the in vitro bactericidal activity against S. aureus, S. Epidermidis, E. Faecium, E. coli, P. Aeruginosa, Enterobaceter cloacae and Klebsiella oxytoca in forearm colonization. After 2 days of application of honey, the extent of colonization was reduced 100-fold. Apparently, honey has other uses too and has been reported to successfully treat chronic wound infections that were unresponsive to antibiotics. Who would have thought? Perhaps this could have also made a ShortCuts section in the year 1776….

The article was published by a group of researchers in Amsterdam; somehow it makes perfect sense.

Tuesday, July 1, 2008

Lucian, you're like no other

Excerpts from an interview with Lucian Leape – an adjunct professor of health policy at Harvard School of Public Health – in a 2007 issue of Health Affairs.

[Buerhaus, Peter I. Is Hospital Patient Care Becoming Safer? A Conversation with Lucian Leape. Health Affairs. 26;6 (2007):687-96.]

Dr. Leape is well known for his ground-breaking research and thinking about patient safety, particularly on the need to focus on systems of care to prevent injury to patients, and, more recently on the need for full, open disclosure and apology when things go wrong.

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On reducing medical error to 0:

The most exciting thing that has happened recently in patient safety--something that has truly changed our agenda--is that it is now apparent that we can use perfection as a benchmark. This means that we can stop talking about reducing medication errors by 50 percent or improving hand washing by 30 percent, and so forth. We now have convincing demonstrations that when the effort is made and new practices are implemented, we can actually eliminate certain adverse events. There is no reason to think that this cannot be expanded to the whole universe of adverse events.

On disclosure of medical errors and patient safety:

The need for full disclosure and compensation is finally on the patient safety agenda. Acknowledging mistakes when they occur, fully explaining what happened, apologizing for errors, and providing compensation for the cost of the injuries we cause are things that we have to do. Patients too often do not get the truth, the whole truth, and nothing but the truth, and it is time to stop that.

There are many reasons why physicians have been reluctant to be open and apologize after accidental injury, but a major factor has been bad advice from liability insurance carriers and hospital counsels, who have perpetuated the myth that informing the patient will increase the likelihood of being sued. There is not a shred of evidence to support this assertion--not a single study--yet the myth dies hard.

Although fear of litigation is very real, and understandable, I believe that a more powerful reason that doctors sometimes do not communicate fully with patients after a serious error is their sense of shame and guilt. Physicians hold themselves to high standards of performance. As a result, they find it difficult to deal with failure. And they get very little support, either from their colleagues or from risk management personnel. It turns out that full disclosure and apology when there has been an error are important for the physician as well as for the patient. We need to provide them with support to help make it happen.

On Pay for Performance (P4P) models of health care:

Essentially, it suggests that you can get quality by paying for it. The idea seems sound, but whether the results will confirm it remains to be seen. It certainly is a concept worth trying, given that our current system of paying for health care is rife with perverse incentives. As some wag observed, health care is the only industry where you get paid more for a defective product! But, it's true: Hospitals and doctors receive more income when things go wrong than when they go right. And it works both ways: You get paid less for good care. That is clearly not what we want.

Here is a classic example: A doctor does a good job treating patients with asthma, teaching them to manage themselves, and the end result is exactly what we want--patients have fewer attacks. They are not going to the doctor's office as often, they are not going to the emergency room, and they are not being admitted to the intensive care unit and being intubated. But the net result is that both the doctor and the hospital lose money. That does not make any sense, and we need to change that. Our fee-for-service system also emphasizes providing services rather than providing care, and that also needs to be changed. We should pay for good-quality care.

On the major flaws of current - and potentially all - P4P proposals:

Pay-for-performance, though, has some major problems that we have to sort out. I do not know how they are going to be resolved, but let me at least briefly mention a few. The first is whether you should pay for process or for outcomes. Second, how do you pay: Do you pay a bonus for good care, or do you punish people who fail?

Let us say you pay a bonus for somebody who does a better job of making sure that all patients who have a heart attack get beta-blockers afterward. We have pretty good data that this makes a difference in outcomes, so one thing to do is say, "If you achieve a high level--say, over 90 percent of your patients get beta blockers--we will pay a premium." Or do you not worry about that and focus on outcomes?

I am also concerned about the possibility of perverse effects. Any time you change payment, you change behavior, and that often has unintended consequences. If we concentrate on paying for outcomes, will we in effect devalue and direct attention away from the "soft stuff" that means so much to patients: time spent listening to them, caring about them, communicating with them? If we do not pay for that, then is it going to be diminished? I would hope not, but one must be aware of that possibility.

On the power of data collection as an engine of change in health care settings:

The second [effective] approach [to progress in healthcare quality and safety], which is even more powerful, is data and feedback. Everybody in medicine, perhaps everybody in health care, thinks they are from Lake Wobegon--that they are "above average." It is very hard for any doctor, for example, to be called average. And when they find out from the data that they are below average, they begin to do something about it.

And finally, on one of the major shortcomings of the current state of medical education:

The third barrier is that students in medicine, nursing, and pharmacy receive insufficient basic education in quality and safety. At a minimum, in the first year of school, all of them should learn the basics of error theory, why people make mistakes, and how to prevent them. Later, they should learn how to analyze systems, how to identify systems' failures, and how to redesign systems. As we mentioned, they need to learn how to work in teams by doing it, and doctors especially need to learn the basics of leadership. They need to learn much more about how to communicate more effectively, how to handle their own feelings and concerns, and how to handle the shame and guilt they will feel when things go wrong, so that they can still be effective caregivers. They need to learn how to apologize. These are things that are currently not being taught to our budding doctors. That has to change.

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Oh man -- Dr. Leape presents puts forward so many outrageously smart and forward-thinking ideas in this interview. I hadn't come across his work until I started working with the Patient Safety and Risk Management teams at this hospital, but some very similar thoughts have been fermenting in my brain (albeit, phrased far less articulately) since my time in South Africa - especially after my experiences working alongside members of the Institute for Healthcare Improvement's developing countries team.

Sunday, April 6, 2008

Socially responsible physicians

My dad forwarded me an invitation to a talk at NYU -- my likely future medical school -- taking place this afternoon. The title of the lecture being given by Dr. Erica Frank intrigued me, and I've decided to go down and check it out.
In fact, a little preemptive internet research has revealed a bit more about what we'll likely be hearing about tonight. Very different than what I might have imagined from a talk including the phrase 'Climate Change' in it's title -- but an extremely important message all the same. Dr. Frank believes that physicians who preach what they practice (good diet and exercise habits; environmental consciousness) are more effective at providing care than those physicians who do not model these behaviors. I 'm not sure if I'm one hundred percent on board with her hypothesis off the bat, but I'm sure she'll have lots of interesting things to say in just a few short hours.

On a related note: I'm very much looking forward to getting back into school mode. Listening to interesting lectures and trying to wrap my mind around difficult concepts sounds like an exciting change of pace at the moment. I'm sure I'll be regretting these sentiments come August, but for now this evening's lecture will be a real treat. Holler.

From the Medscape Journal of Medicine:

Erica Frank, MD, MPH, Professor and Canada Research Chair; Founder and Executive Director; Founder and Principal Investigator; President-Elect

Physician well-being, patients' preventive care, and global warming: What do these 3 issues have in common? Both physician well-being and patients' preventive care are important contributors to climate change. Here's how it goes:

First, physician well-being: Contrary to myth, US physicians tend to live several years longer than nonphysicians, largely because we typically do have very good health habits; for example, very few of us smoke – about 4% of doctors in the States.

But there are 2 other important areas where our habits are better than others' but could still use considerable improvement. These are diet and exercise.

Second, patients' preventive care: Physicians tend to preach to patients what we ourselves practice. Many studies have now shown that (starting with freshman medical students) physicians with healthy personal habits are more likely to encourage our patients to adopt such habits.

This is specifically true for both diet and exercise: Physicians who eat less fat are half as likely to test patients' cholesterol,and those who exercise more are significantly more likely to counsel their patients about exercise. And it's also been shown that patients find doctors with healthier diet and exercise habits to be more believable and more successfully motivating in both diet and exercise.

So the last, the healthy climate preservation part, then is, if you eat lower on the food chain by eating less meat and more locally grown fruits and vegetables, and if you walk or bike more instead of driving, we will help our patients consume fewer resources and pollute less, too.

So, while behavioral change is complex, it's clear that our personal actions as physicians, and the way that our actions help our patients make better choices, are a good place to start healing ourselves, our patients, and our planet.

That's my opinion. I'm Dr. Erica Frank, Professor and Canada Research Chair at the University of British Columbia, and Founder and Principal Investigator of the Healthy Doc = Healthy Patient initiative.

Tuesday, April 1, 2008

A brief word about autism.

It has long been known that advancing maternal age is associated with an increased risk of genetic disorders in children. I haven't done enough research to tell you the precise mechanism(s) for this genetic degradation, but it seems clear that as eggs age their chromosomal material becomes less stable.

Similar studies on paternal age have been recently conducted, and the results have been surprisingly analogous: advanced paternal age is associated with an increased risk of Autism Spectrum Disorders (ASD). Researchers have even identified possible biological mechanisms, including de novo mutations associated with advancing age or alterations in genetic imprinting.

The most important important article on the subject can be found here on the Archives of General Psychiatry website.

It is important that this result be publicized as widely as possible for a number of reasons. Firstly, and most significantly, the number of autistic children is rising rapidly in the US and around the world. Secondly - and as a direct result of this unprecedented rise in ASD children - we have heard from an unfortunately large number of highly unscientific sources that regular childhood vaccinations might be contributing to the increasing number of autistic children. This unfounded concern has in turn led to a fewer parents immunizing their children, thus increasing the likelihood of an outbreak of measles or other traditionally childhood illness. There is absolutely no scientific evidence showing causal association between the measles-mumps-rubella vaccine (or the vaccine preservative thiomersal) and autism.

Hopefully as this finding - coupled with ongoing research in the field - is disseminated, it will finally convince parents and (malpractice-averse) physicians alike that Autism Spectrum Disorders are related to genetic mutations, most likely occurring during spermatogenesis.

My apologies if it feels like this post isn't fleshed out enough. I just wanted to get down some quick thoughts on the subject while it was on my mind. If you have any specific questions about the underlying science or research principles of anything you've read about, I would be happy to discuss them more thoroughly and/or in a way that doesn't rely on as much pre-existing understanding of medical biology. That's all for now.

Wednesday, March 12, 2008

post and run

This is the same old story about TB and HIV in Africa, this time in the the world's foremost medical journal. Never has a broken record approach been so important. This week's New England Journal article is entitled "Tuberculosis in Africa — Combating an HIV-Driven Crisis" (click for full text).

Tomorrow I'm off to Florida and then the Bahamas to see family and friends. I must admit, I'm very excited for SPRING BREAK!! I'll even have a better sense of the med school landscape when I return. I'm reluctant to let my parents open those admissions envelopes, but I imagine that's what will happen. I'll be sure holler on the flip side.

Sunday, October 21, 2007

Verses from the Abstract

What follows are some exciting excerpts from the very first abstract to come out of the TB-HIV coinfection study I've been working on for the past 10 months. The finding described in the abstract - essentially, that there is a great deal of death and unexplained drop-out among patients poised to begin antiretroviral therapy (ART) in the clinic we've been working in - actually has little to do with TB in particular, although many of the mortalities described in the abstract were of HIV-positive patients thought to have active cases of TB.

This abstract has already been submitted for one of the big AIDS conference taking place in the United States in early 2008. Hopefully we'll be hearing back relatively soon if it was accepted or not!

I'm so not ready to leave this place just yet.

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Loss to Care and Death before ART: Patients Eligible for Treatment Who Do Not Make it in Durban, South Africa

Background: Early losses from care during antiretroviral therapy (ART) have been described for patients attending HIV or ART clinics in resource-limited settings. Our objective was to examine the loss to follow-up and mortality rates among ART-eligible patients who have not yet started therapy.

Methods: We performed a retrospective chart review for all HIV-infected adults who were eligible for ART training and treatment (CD4 ≤ 200/μl or clinical criteria) at an urban HIV clinic in Durban, South Africa from July-Dec. 2006. Patients who did not start ART and were lost to care prior to or within 3 months of the 1st of 3 ART training visits were phoned to ascertain their status.

Conclusions: Loss to follow-up and death occur frequently following first CD4 count but before starting ART in Durban, South Africa. Time from CD4 count to the initiation of ART training is months, even in those with the lowest CD4 counts. Interventions that improve linkage to care and prioritize ART initiation for those with low baseline CD4 counts are needed.

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As Q-Tip once famously said:

I'm movin, yes I'm groovin', becacuse my mouth is on the motor/
Use the Coast in the mornin' to avoid the funky odor/
Can't help bein' funky, I'm the funky Abstract brotha/

word.

Thursday, September 27, 2007

Upgrade U

I'm still nursing this sore throat - my voice has that distinctively pubescent squeak to it - and I don't feel like I have much to contribute at the moment. So in lieu of my thoughts: here are a few items that are marginally more interesting than anything I have to say right now.

#1 An article in the American Journal of Epidemiology about how Cuba's economic crisis of the 1990's has led to dramatic country-wide decreases in cardiovascular disease and diabetes. More good analysis can be found here. One of the the less obvious corollarys of this article is that if we are to believe the papers' conclusions, we must also accept that obesity is not only a genetic condition. Instead, weight is the consequence of environmental and genetic interactions, and that environment - including diet and exercise - play large roles.

#2 There are some bad-ass surgeons living in Melborne, apparently. Five Australian surgeons at the Royal Melbourne Hospital removed this metal chair leg from a 20 year-old patient's eye socket, saving both the man's life and, miraculously, his eye - which had, I guess, been pushed aside at impact. The procedure was more than four hours long - including the reconstructive plastic surgery - and the guy walked out of the hospital 19 days later with 95% vision in the damaged eye. While I would still recommend not getting into brawls outside of nightclubs, it's pretty miraculous to think that modern medicine has developed the tools to repair such catastrophic injuries to the human body.

Isn't this a haunting image? Huh, I wonder if the radiologist saw the pathos.

#3 Gβ5-RGS complexes co-localize with mGluR6 in retinal ON-bipolar cells. Morgans C, Bearnot BI, et al. Coming soon to a copy of the European Journal of Neuroscience near you. Oh, you don't get that one? Neither does anybody. This was basic science research I did out at the Neurological Sciences Institute at OHSU in 2004 - but I'm really glad that they're finally getting around to publishing it. I feel like I did some mean confocal microscopy work that summer.

Sunday, September 16, 2007

Red vs. Blue

This is what the problem looks like:

(from Corbet et al. Lancet 2006; 367: 926–37)


...and things have only gotten worse since 2000. I've seen many many charts and graphs about the problem of TB-HIV coinfection around the world - but is the most effective at visually demonstrating Southern Africa's disproportionate burden of this developing TB-HIV pandemic. The article that I pulled this figure from is one of the best I've come across, and has been tremendously helpful in putting together this presentation for all of my coworkers in the ARV decentralization project. Hopefully I'll get around to posting some of those slides when I finish them up.

Back to work. Holler.